Further Investigation of FAS-Associating Death Doman-Like Interleukin-1𝛽-Converting Enzyme, A Homologous ICE/CED-3-Like Protease Recruited to the CD95 (FAS/APO-1) Death=Inducing Signaling Complex
MetadataShow full item record
Previous research has identified CAP3 and CAP4, components of the CD95 (Fas/APO-1) death-inducing signaling complex, by the use of nano-electrospray tandem mass spectrometry, a recently developed technique to sequence quantities of polyacrylamide gel-separated proteins. Interestingly, CAP4 encodes a novel 55kDa protein, designated FLICE, which has homology to both FADD and the ICE/CED-3 family of cysteine proteases. FLICE binds to the death effector domain of FADD and upon overexpression induces apoptosis that is blocked by the ICE family inhibitors, CrmA and z-V AD-fink. CAP3 was identified as the FLICE prodomain which likely remains bound to the receptor after proteolytic activation. This further investigation provides unique biochemical evidence to link a death receptor physically to the proapoptotic proteases of the ICE/CED-3 family.
Showing items related by title, author, creator and subject.
Gaucher, Alexander (Kalamazoo, Mich. : Kalamazoo College, 2015)The Disease we now know as the Black Death was one of the most statistically devastating diseases of the past millennuim. In terms of sheer numbers, other diseases, like the Spanish Flu, might surpass it; but when it comes ...
VanGelderen, Benjamin Frederick (Kalamazoo, Mich. : Kalamazoo College, 2010)It is difficult to separate the gladiatorial combats from the venationes because once the venationes became part of the shows, they almost always occurred together. Many of the explanations for the beast fights are shared ...