The Loss of Heterozygosity on Chromosome Regions 3p, 5q, 8p, 9p, l0p, l8q, and 2lq in Squamous Cell Carcinoma of the Head and Neck
Dryer, Richard R.
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Squamous cell carcinoma affects 60,000 persons each year in the United States. Squamous cell carcinoma of the head and neck (SCCHN) accounts for 10% of all cancers and 5% of malignant neoplasms and cancer deaths in the Western World. Cancer is a genetic disease that is frequently the result of mutations on chromosome regions that contain tumor suppressor and tumor associated genes. These gene loci are located on chromosome regions 3p, 5q, 8p, 9p, 10p, 18q, and 21q. In the present study, we analyzed 4 SCCHN patients with the polymerase chain reaction and restriction fragment length polymorphism for loss of heterozygosity at 21 microsatellite markers located on the aforementioned chromosomes. In informative cases we observed LOH at four specific chromosome regions: 3p13 (50%); 3p14.1-p14.3 (25%); 8p21 (50%); and 9p21-p23 (42%). These results suggest that gene loci 3p13, 3p14.1-p14.3, 8p21, and 9p21-p23 harbor tumor suppressor and tumor associated genes that are important in the tumorgenesis of squamous cell carcinomas of the head and neck.