The Effects of Progesterone on the Growth Factor, Granulin, in Various Tissues of BALB/c Mice
Athappilly, Geena K.
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Although progesterone's physiological effects on certain tissues have been discovered, its action on other tissues as well as the exact mechanism of action on target tissues has yet to be elucidated. It is postulated that progesterone exerts its characteristic proliferative and differentiating effects by inducing growth factors and oncogenes via the progesterone receptors (PR). This project attempted to explore progesterone's effects on the growth factor, granulin. In order to elucidate this relationship, reverse transcriptase-polymerase chain reaction and northern hybridization were performed on RNA extracted from progesterone-treated and control mice. The understanding of progesterone's effects on granulin will provide important insight into progesterone's physiological functions and potential mechanisms of action. Furthermore, progesterone's observed effects on granulin will be useful in elucidating progesterone's co-carcinogenic or anticarcinogenic effects on cancer growth.