A Comparisonof Pulmonary Functions, Before and After Bronchodilator, Using Small- and Large-Particle Nebulizers, Driven with Either Air or 80%He-20%O2 on Patients with Reversible Airways Disease
Franseen, Laura E.
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In this project, we will study aerosol bronchodilator therapy with two objectives in mind. The first is to study the effects of a helium-oxygen mixture as a carrier gas for the delivery of aerosol bronchodilator, and the second is to compare patients' responses to bronchodilator delivered by large- and small-particle nebulizers. The physiological responses to the aerosol bronchodilator Bronkosol the airways of patients with reversible, obstructive airways diseases, will be assessed. Two nebulizers, the Inspiron and the Eastfield, will be used to dispense large and small particles, respectively. Table I lists the specific measurements that will be made from forced spirograms and flow-volume loops (Figures I and 2). The studies will be performed using air, then an 80%He-20%O'2 mixture as carrier gases in the aerosol treatment.