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dc.contributor.advisorHess, Richard A.
dc.contributor.advisorEbert, Paul
dc.contributor.authorPoffenberger, Rodney James
dc.date.accessioned2012-02-03T21:10:33Z
dc.date.available2012-02-03T21:10:33Z
dc.date.issued1982
dc.identifier.urihttp://hdl.handle.net/10920/24808
dc.descriptionv, 27 p.en_US
dc.description.abstractHematoporphyrin is a photosensitizing agent known to preferentially accumulate in cancer tissue. Recent clinical experiments using hematoporphyrin and light treatment on various types of cancer tumors have shown promising results. The potential uses or porphyrins in detection and treatment of cancer are many. Wavelength variation and succinyl acetone treatment effects on photosensitive killing or 11210 mouse leukemia cells in the presence of hematoporphyrin were investigated. Differences in killing effects were noted between the various wavelengths tested. A direct relationship of increased killing of cells with increased concentrations of hematoporphyrin and longer light exposure times was seen. Succinyl acetone, which increases heme uptake into L1210 cells, decreased the amount of light or hematoporphyrin needed to kill the cells. A reciprocal relationship was seen between serum concentration and light exposure time needed to kill the cells.en_US
dc.description.sponsorshipNational Institutes of Health. Bethesda, Maryland.
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen_US
dc.relation.ispartofKalamazoo College Health Sciences Senior Individualized Projects Collection
dc.relation.ispartofseriesSenior Individualized Projects. Health Sciences;
dc.rightsU.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder. All rights reserved.
dc.titleWevelength and Succinyl Acetone Effects on Photosensitivity Killing of L1210 Cells in the Presence of Hematoporphyrinen_US
dc.typeThesisen_US
KCollege.Access.ContactIf you are not a current Kalamazoo College student, faculty, or staff member, email dspace@kzoo.edu to request access to this thesis.


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