Wevelength and Succinyl Acetone Effects on Photosensitivity Killing of L1210 Cells in the Presence of Hematoporphyrin
Poffenberger, Rodney James
MetadataShow full item record
Hematoporphyrin is a photosensitizing agent known to preferentially accumulate in cancer tissue. Recent clinical experiments using hematoporphyrin and light treatment on various types of cancer tumors have shown promising results. The potential uses or porphyrins in detection and treatment of cancer are many. Wavelength variation and succinyl acetone treatment effects on photosensitive killing or 11210 mouse leukemia cells in the presence of hematoporphyrin were investigated. Differences in killing effects were noted between the various wavelengths tested. A direct relationship of increased killing of cells with increased concentrations of hematoporphyrin and longer light exposure times was seen. Succinyl acetone, which increases heme uptake into L1210 cells, decreased the amount of light or hematoporphyrin needed to kill the cells. A reciprocal relationship was seen between serum concentration and light exposure time needed to kill the cells.