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dc.contributor.advisorKolaja, Gerald J.
dc.contributor.authorBirtman, Mark A.
dc.date.accessioned2012-02-03T20:32:51Z
dc.date.available2012-02-03T20:32:51Z
dc.date.issued1982
dc.identifier.urihttp://hdl.handle.net/10920/24805
dc.description64 p.en_US
dc.description.abstractThe role of the divalent calcium ion in cell injury and death, the subject of much ongoing research, was considered in the present study. The primary hepatocyte culturing system was chosen as the in vitro means of studying the effect of calcium in cell injury and death mediated by a toxin. Two toxins of established mechanisms of toxicity, the ionophore A23187 and lysolecithin, were chosen as the hepatotoxic agents. The results showed that the presence of extracellular calcium enhanced toxic cell death. In an additional set of experiments a calcium binding agent, lodoxamide, was added to determine if the cells could be protected against the effect of calcium. The results from these experiments show a tendency of lodoxamide towards protecting the cells against the effect of calcium.en_US
dc.description.sponsorshipUpjohn Company. Kalamazoo, Michigan.
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen_US
dc.relation.ispartofKalamazoo College Health Sciences Senior Individualized Projects Collection
dc.relation.ispartofseriesSenior Individualized Projects. Health Sciences;
dc.rightsU.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder. All rights reserved.
dc.titleCalcium Dependence in Hepatocellular Injury and Deathen_US
dc.typeThesisen_US
KCollege.Access.ContactIf you are not a current Kalamazoo College student, faculty, or staff member, email dspace@kzoo.edu to request access to this thesis.


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