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dc.contributor.advisorShafie, Samir M.
dc.contributor.authorCavacece, John A.
dc.date.accessioned2012-02-02T19:46:29Z
dc.date.available2012-02-02T19:46:29Z
dc.date.issued1979
dc.identifier.urihttp://hdl.handle.net/10920/24782
dc.descriptionv, 24 p.en_US
dc.description.abstractInsulin has been shown to increase the activity of cyclic AMP phosphodiesterase (PDE) in various rat tissues. It apparently does this by interacting with membrane bound receptors which activate a membrane bound PDE, increasing its activity by raising its Vmax. This membrane bound PDE has been found to be a "low Km" variety of PDE among several other PDE activities. The effect of insulin on POE activity is of importance because of the discovery that cAMP levels have an effect on cell growth, both normal and abnormal. This is of importance in the study of certain hormone-responsive types of cancer. In this study the purpose was to test the effect of insulin on PDE activity on Michigan Cancer Foundation No.7 (MCF7) human mammary cancer cells after first establishing whether or not the cells exhibited multiple PDE activities. The multiple PDE activities were found, but insulin effect was negligible in any at all.en_US
dc.description.sponsorshipLaboratory of Pathophysiology. National Cancer Institute. National Institutes of Health. Bethesda, Maryland.
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen_US
dc.relation.ispartofKalamazoo College Health Sciences Senior Individualized Projects Collection
dc.relation.ispartofseriesSenior Individualized Projects. Health Sciences;
dc.rightsU.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder. All rights reserved.
dc.titleEffects of Insulin on Cyclic 3'-5- AMP Phosphidiesterase in Relation to Mammary Carcinomaen_US
dc.typeThesisen_US
KCollege.Access.ContactIf you are not a current Kalamazoo College student, faculty, or staff member, email dspace@kzoo.edu to request access to this thesis.


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