Hormonal Physiology of the Male Reproductive System: Toward Development of a Hormonal Contraceptive
Mauti, Steven A.
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This review of the physiology of the male reproductive system stresses the importance of the Sertoli cells, the Leydig cells, and the epididymus in research directed toward a male chemical contraceptive pill. This pill, when developed, will exert its actions within the hypothalamal-pituitary-gonadal axis. This axis regulates the system hormones: follicle stimulating hormone, luteinizing hormone, testosterone, and its metabolites, and other less potent hormones. Research now being done indicates that a few chemicals, alone or in combination with testosterone, are very promising for future use as contraceptives. However, in order for such a chemical to be acceptable and have an impact on world population, several problems such as health risks, cost, and method of administration must be worked out.
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