Studies on the Anticancer Effects of Ifosfamide
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The drug ifosfamide is currently being used on an experimental basis at Borgess Hospital, Kalamazoo, Michigan, for the treatment of lung cancer. A question arose as to whether the drug is more effective if administered in a treatment course consisting of a single large dose, as opposed to smaller doses on several consecutive days (fractionated dose schedule). To elucidate this matter, a laboratory study was undertaken employing Lewis Lung Carcinoma, a solid tumor which, after implantation in the leg, metastasizes to the lungs. The original intent was to use animal survival time as the criterion for comparing the anticancer effects of the two dosage schedules, with counts of pulmonary metastases present at death providing additional information. However, differences observed between the two schedules with regard to tumor control prompted a second study, which employed repeated courses of treatment. The apparent greater effectiveness of the single dose schedule was indicated by the animal survival times in both studies, and, in the second study, by the number of pulmonary metastases and the control of tumor growth. There were, however, difficulties associated with the interpretation of the results regarding animal survival time and number of pulmonary metastases.