The Effect of 12-0-Tetradecanoyl Phorbol-13-Acetate on DNA Excision Repair Replicaiton in Primary Mouse Epidermal Cell Cultures

Abstract

In the present experiment, the effect of TPA on repair replication is again studied with Gaudin's proposed theory of promoter action in mind. The distinguishing feature of this experiment, however, is the use of mouse epidermal cells, a target cell type for the action of tumor promoters. The supporting theory was that TPA may have a different effect on repair replication in a target tissue than in a non-target tissue (Bowden, 1976).