The Effect of Bacillus Calumette-Guerin on the Humoral Immune Response in Mice
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Authors
Johannessen, Lynne C.
Issue Date
1975
Type
Thesis
Language
en_US
Keywords
Alternative Title
Abstract
The effect of priming with Bacillus Calmette-Guerin (BCG) on the
magnitude of direct plaque-forming cell (dPFC) response to thymus-derived
(T) cell-independent and T cell-dependent antigens in athymic
nude and heterozygous nude mice was measured. Immunization of both BCG
and antigen in the right hind foot pad resulted in an enhanced response
in the popliteal lymph node. This enhanced response occurred only in
the heterozygote and only with T cell-dependent antigens. A decreased
splenic dPFC response to T cell-dependent and T cell-independent
antigens was elicited in both nude and heterozygous nude mice. Organ
cell counts were significantly higher in BCG-primed animals as compared
to unprimed controls. Splenic suppression was not dependent on the
dose of BCG administered and could not be elicited using an inoculum of
killed BCG although the enhancement witnessed in the lymph node was
maintained.
These findings suggest the presence of a suppressive factor
which is limited to the spleen and whose effect is not dependent on the
presence of thymus-derived cells.
Description
iv, 24 p.
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