The Effect of Coagulation Parameters upon theAddition of Supplemental Albumin to a Standard Resuscitation Regimen for Hypovolemic Shock
Staricco, Renato James
MetadataShow full item record
Using clotting factor assays and screening tests it was found that the addition of supplemental albumin to a standard resuscitation regimen for hypovolemic shock resulted in a decrease in clotting factors. Plasma samples of twenty-one dogs were tested. Samples were taken ten days prior to shock (control sample A), immediately after shock and treatment with Basic Electrolyte Solution (BES) or 5% albumin in BES (sample B), 24 (sample C), 48 (sample D), and 72 (sample E) hours after shock. Prothrombin Times, Activated Partial Thromboplastin Times, Thrombin Times, Fibrinogen Assays, Factor VIII Activities, Antithrombin III Assays, Plasminogen Assays, and Protamine Sulfate Tests were run on the plasma samples. Results indicate that fibrinolysis did not increase. Instead, there is apparently a decrease in synthesis of coagulation proteins by the liver.