Two-Dimensional Electrophoresis of Normal and Diabetic Human Platelet Protein
Colman, Robert A.
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In an attempt to determine differences between platelet protein patterns of 15 diabetic and 11 non-diabetic age-matched subjects, a study was undertaken utilizing the Iso-Dalt System of two-dimensional gel electrophoresis. The 26 resulting protein patterns were visually compared resulting in no consistent differences in terms of amount or location of proteins between diabetics and age-matched controls. A diabetic vs. control protein difference present within 75% of the subjects suggests a necessity for further research, possibly involving a more sensitive gel staining procedure currently being developed. ,