Liquid Tissue Mechanics as a Factor in Morphogenetic Tissue Movements in the Chick Embryo
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Authors
Johnson, Keith
Issue Date
1981
Type
Thesis
Language
en_US
Keywords
Alternative Title
Abstract
Recent evidence suggests that developing tissues in the
chick embryo resemble multicellular liquids. It has been
suggested that surface tensions in the tissues direct tissue
position and growth in the embryo. Developing heart, liver
and limb bud may act as more cohesive elasticoviscous liquid
droplets in less cohesive mesodermal tissue layers. Direct
evidence for this hypothesis is found in a specific hierarchy
for the differential adhesion of unlike tissues in in vitro
culture. The elasticoviscous liquid nature is proved through
electron and light micrographs of aggregates compressed
under centrifugation. Direct quantitive values for the intercellular
forces have been impossible to calculate,until now.
Using methods developed in the last several years, this study
was an attempt to measure these quantitative values using
parallel plate compression of multicellular aggregates in a
miniature vise. The significance of this research is primarily
in .the area of morphogenetic movements in.the developing
embryo, primarily chick limb bud formation, although
possible significance in the mechanism of metastasizing
tumors is indicated.
Description
iii, 31 p.
Citation
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License
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