The Role of Arachidonic Acid and Phospholipase a2 in Compound 48/80-Induced Release of Histamine from Rat Peritoneal Mast Cells
Norbury, James Eric, III
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The purpose of this thesis is to produce evidence for the role of phospholipase A2 and arachidonic acid in histamine release from mast cells. Rat peritoneal mast cells are treated with inhibitors of phospholipase A2 action in hopes of achieving a concomitant inhibition of histamine release. The demonstrated inhibition is sought to be reversed by addition of a product of the phospholipase's activity; arachidonic acid. If such a reversal of inhibition of histamine release will take place, then it would seem that one step in the sequence.of histamine release is mediated by phospholipase A2.