The Cutaneous Irritation Potential of Topical Anti-Inflammatory Agents in Mice and Rats
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In this paper two experiments examining the primary cutaneous irritant action of several topical anti-inflammatory agents are presented. The anatomy and physiology of the skin, the process of inflammation, and some general aspects of dermatologic therapy will also be discussed. In the first study, the cutaneous irritation potential of various concentrations of cycloheximide in the mouse were examined. Cycloheximide is an antibiotic substance marketed as Actidioneo It is a product of the beers of Streptomyces griseus and is used currently as an agricultural fungicide. Cycloheximide inhibits protein synthesis by preventing amino acid incorporation. Because of its anti-mitotic activity, cycloheximide is currently being examined for use in the treatment of psoriasiso Cycloheximide produces toxic effects when used systemically, but is topically active. This aspect of cycloheximide for the treatment of psoriasis is currently being analyzed by the Upjohn Company. The second study examined the cutaneous irritation potential of topical corticosteroid preparations. in the rat. Topical formulations of U-34,865, an anti-inflammatory corticosteroid compound currently being tested by the Upjohn Company, and several marketed corticosteroid preparations were employed.