The Cutaneous Irritation Potential of Topical Anti-Inflammatory Agents in Mice and Rats
Loading...
Authors
Dumont, Janin
Issue Date
1975
Type
Thesis
Language
en_US
Keywords
Alternative Title
Abstract
In this paper two experiments examining
the primary cutaneous irritant action of several
topical anti-inflammatory agents are presented.
The anatomy and physiology of the skin, the
process of inflammation, and some general aspects
of dermatologic therapy will also be discussed.
In the first study, the cutaneous irritation
potential of various concentrations of cycloheximide
in the mouse were examined. Cycloheximide
is an antibiotic substance marketed as Actidioneo
It is a product of the beers of Streptomyces
griseus and is used currently as an agricultural
fungicide. Cycloheximide inhibits protein synthesis
by preventing amino acid incorporation. Because
of its anti-mitotic activity, cycloheximide is
currently being examined for use in the treatment
of psoriasiso Cycloheximide produces toxic effects
when used systemically, but is topically active.
This aspect of cycloheximide for the treatment of
psoriasis is currently being analyzed by the Upjohn
Company.
The second study examined the cutaneous irritation
potential of topical corticosteroid preparations.
in the rat. Topical formulations of U-34,865, an
anti-inflammatory corticosteroid compound currently
being tested by the Upjohn Company, and several
marketed corticosteroid preparations were employed.
Description
v, 48 p.
Citation
Publisher
License
U.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder. All rights reserved.