Antibiotic Therapy for an Experimental Streptococcus Milleri Subcutaneous Abscess in Mice
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A Streptococcus milleri subcutaneous abscess model in mice was developed using gelatin microcarriers as abscess-promoters. Microcarriers were essential to the formation of large and highly reproducible abscesses. Histological examination of the developing S. milleri abscess revealed similarities which have been observed in humans, such as a substantial host inflammatory response and the appearance of a protein capsule. The kinetic analysis of bacterial and host cell populations in the abscess revealed the host's ability to control successfully bacterial spread and replication by the action of phagocytic cells followed by structural containment of the bacteria. Of the antibiotics that were evaluated in this model, imipenem was most effective at preventing abscess formation while rifampin and clindamycin were most effective at curing established abscesses.