Effects of Trimethyltin and Noise on Auditory Function
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Authors
Proctor, Brian D.
Issue Date
1986
Type
Thesis
Language
en_US
Keywords
Alternative Title
Abstract
General mechanisms of otoxicity have not yet been
determined. Because of the similar recovery times of
trimethyltin exposure and of noise exposure it was suspected that
both insults followed a common pathway in damaging the auditory
system. Male rats were exposed to a combination of trimethyltin
(4mg/kg) and noise (102 db) and then examined behaviorally and
histologically. The histological study showed permanent damage
(phalangeal scars) in the middle and basal turns of the cochlea.
The behavioral tests, based of the phenomenon of reflex
modulation, showed the expected loss in subjects exposed to the
trimethyltin alone of the noise alone. If a common pathway
existed between trimethyltin and noise induced auditory damage, a
more than additive effect would be seen when the two insults are
given together. When a combination of trimethyltin and noise
exposure was employed the subjects demonstrated at least an
additive hearing loss. These results imply that the two insults
do not follow a common mechanism but may actually damage two
separate types of cells in the ear.
Description
vi, 43 p.
Citation
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License
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