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dc.contributor.advisorHudson, Richard A.
dc.contributor.authorZusman, Neil
dc.date.accessioned2012-01-27T18:59:50Z
dc.date.available2012-01-27T18:59:50Z
dc.date.issued1980
dc.identifier.urihttp://hdl.handle.net/10920/24713
dc.descriptionviii, 75 p.en_US
dc.description.abstractNeurotoxin-3 from the venom of the Thailand Cobra, Naja naja siamensis, was reduced and S-carboxymethylated prior to undergoing digestion by trypsin. The resulting five major tryptic peptide fragments were partially separated chromatographically and their ability to bind to the acetylcholine receptor site (AchR) was examined. Results based on a 30-min. time point seemed to indicate that some of the peptides inhibit the binding of 125 I-α- bungarotoxin to the AchR at concentrations in the range of 10-6 - 10-4 M. One particular peptide, which is thought to contain the majority of important residues making up the "toxic loop," exhibited pronounced inhibition. Results from a kinetic binding study indicated that this peptide possibly exhibits inhibition at a concentration in the range of 3. 46 X 10 -6 - 6 .91 X 10 -6 M.en_US
dc.description.sponsorshipDepartment of Biochemistry. Wayne State University. Detroit, Michigan.
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen_US
dc.relation.ispartofKalamazoo College Health Sciences Senior Individualized Projects Collection
dc.relation.ispartofseriesSenior Individualized Projects. Health Sciences;
dc.rightsU.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder. All rights reserved.
dc.titleTryptic Peptide Fragments of the Principal Curarimimetic Neurotoxin from the Venom of the Thailand Cobra, Naja Naja Siamensisen_US
dc.typeThesisen_US
KCollege.Access.ContactIf you are not a current Kalamazoo College student, faculty, or staff member, email dspace@kzoo.edu to request access to this thesis.


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