Thromboxane B2 Biosynthesis in Activated and Normal Mouse Peritoneal Cell Populations
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The activated macrophage is an important component of the host defense system, exhibiting antibacterial, antiviral, and antitumor properties. Many means of activating macrophages are known, but the activation process itself remains obscure. Prostaglandins and thromboxanes are known· to be important in normal cell growth, and evidence exists which indicates that they are also important in abnormal cell growth. In addition , activated macrophages exhibit prostaglandin and thromboxane production which differs from that of normal macrophages. It has been postulated that the prostaglandins released by macrophages could act locally in negative feedback inhibition to limit cell activities and prevent repeated stimulation of macrophages. In addition, prostaglandins and thromboxanes may be involved in a "push and pull" type relationship with lymphocytes and macrophages, acting as mediators between the two cell types. The present study was initiated to determine the differences in TxB2 levels of normal and activated macrophages in neoplastic cell culture. TxB2 levels were found to be higher in activated macrophages, suggesting that TxB2 may be involved in the activation process or as an intra-cellular mediator.