The Effects of Halothane and Ketamine Anesthesia on a Hypertrophied Right Ventricle
Green, Lance D.
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Presently, halothane and ketamine are two of several commonly used anesthetic agents for cardiac catheterization of patients with congenital heart disease leading to right ventricle hypertrophy. Right ventricle hypertrophy pertains to an enlargement of the ventricle to meet increased functional demands usually caused by a stenosis or constriction somewhere within the pulmonary artery. Although the relative effects of halothane and ketamine on the cardiovascular system of patients with normal hearts and patients with various types of congenital defects have been extensively studied, the effects of these agents on the cardiovascular system of patients with hypertrophied right ventricles remain undocumented. In this study chronic right ventr1cle hypertrophy was produced in two week old lambs by constriction of the pulmonary artery. The effects of halothane and ketamine anesthesia were then determined by hemodynamic and myocardial blood flow studies when the animals were between six and twelve months of age.