Development of a Physiologic Method to Study the Phenomena of Supersensitivity of Postsynaptic Dopamine Receptors
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Authors
Hunter, David
Issue Date
1980
Type
Thesis
Language
en_US
Keywords
Alternative Title
Abstract
The rotational model is a useful method for studying
postsynaptic dopamine receptors. 6-hydroxydopamine
lesions induce a supersensitivity, forming of more
receptors, in the postsynaptic dopamine region. This
increase in receptors can be used as a quantitative
method of inducing rotation of rats. D-amphetamine
and apomorphine-hydrochloride are drugs that induce
rotation in a specially designed rotometer.
Haloperidol, a drug used to control schizophrenia,
also induces supersensitivity after chronic administration.
Chronic administration of haloperidol to
rats that have received 6-hydroxydopamine lesions induces
supersensitivity on the non-lesioned but not on the
lesioned side. This is consistent with the hypothesis that the supersensitive or lesioned side cannot
become more supersensitive.
Description
iv, 32 p.
Citation
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