Development of a Physiologic Method to Study the Phenomena of Supersensitivity of Postsynaptic Dopamine Receptors
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The rotational model is a useful method for studying postsynaptic dopamine receptors. 6-hydroxydopamine lesions induce a supersensitivity, forming of more receptors, in the postsynaptic dopamine region. This increase in receptors can be used as a quantitative method of inducing rotation of rats. D-amphetamine and apomorphine-hydrochloride are drugs that induce rotation in a specially designed rotometer. Haloperidol, a drug used to control schizophrenia, also induces supersensitivity after chronic administration. Chronic administration of haloperidol to rats that have received 6-hydroxydopamine lesions induces supersensitivity on the non-lesioned but not on the lesioned side. This is consistent with the hypothesis that the supersensitive or lesioned side cannot become more supersensitive.