Extrathermodynamic and Thermodynamic Studies of Retention Utilizing a C-18 Derivatized Polystyrene-Divinylbenzene HPLC (Act-I) Column
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Authors
Stevens, Joyce Kay
Issue Date
1988
Type
Thesis
Language
en_US
Keywords
Alternative Title
Abstract
Alkane/water partition coefficients have been predicted from
the retention times of solutes, of both small and large molecular
weights, using a C-18 derivatized polystyrene-divinylbenzene HPLC
column (Act-I). π coefficients have been calculated and compared to
literature values. The π coefficients for larger molecular weight
compounds are similar to those of smaller compounds. Thus the
retention mechanisms are similar for large and small compounds
even though this system underestimates log PC's for larger
compounds. The thermodynamics of the Act-l column were also
studied. High correlation coefficients (0.988 or higher) were
obtained for plots of log k' versus l/T (K). Deviations of calculated
alkane/water partition coefficients from observed values seem to
depend upon molecular weight, suggesting that special interaction
between the solute and stationary phase are significant.
Description
vi, 32 p.
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