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dc.contributor.advisorFox, David A.
dc.contributor.authorKim, Timothy S.
dc.date.accessioned2012-01-25T16:43:18Z
dc.date.available2012-01-25T16:43:18Z
dc.date.issued1987
dc.identifier.urihttp://hdl.handle.net/10920/24668
dc.descriptioniv, 23 p.en_US
dc.description.abstractClinical studies and animal experiments have shown that the pathogenesis of rheumatoid arthritis (RA) is due to autoimmune responses facilitated by T (thymic-derived) lymphocytes. To characterize novel activation pathway of synovial T lymphocytes, a monoclonal antibody against a rheumatoid synovial T cell line has been produced, termed anti- UM4D4. This antibody recognizes a surface antigen, termed UM4D4, expressed strongly on rheumatoid synovial T cells (50- 95%), while present on only 20-25%% of peripheral blood T cells (Higgs et al., 1988). Careful study of Ca++ flux, Inositol phospholipid turnover, and protein kinase C activation following UM4D4 activation would be the next logical step to further study this activation pathway. In this paper, strong evidence of Ca++ Influx following UM4D4 actlvati0n is presented. Working protocols for Inositol trisphosphate (IP3) and protein kinase C (PKC) assays for UM4D4 activation are also discussed. Detalied structural and functional characterization of the UM4D4 antigen in future could facilitate the greater understanding of T-cell activation in rheumatoid arthritis, necessary for possible novel therapeutic approaches.en_US
dc.description.sponsorshipMedical School. University of Michigan. Ann Arbor, Michigan.
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen_US
dc.relation.ispartofKalamazoo College Health Sciences Senior Individualized Projects Collection
dc.relation.ispartofseriesSenior Individualized Projects. Health Sciences;
dc.rightsU.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder. All rights reserved.
dc.titleSecond Messenger Systems in a Novel t-Cell Activation Pathway Involving the UM4D4 Surface Antigenen_US
dc.typeThesisen_US
KCollege.Access.ContactIf you are not a current Kalamazoo College student, faculty, or staff member, email dspace@kzoo.edu to request access to this thesis.


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