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dc.contributor.advisorMammen, Eberhard
dc.contributor.authorHalasz, Susan Patricia
dc.date.accessioned2012-01-25T15:55:53Z
dc.date.available2012-01-25T15:55:53Z
dc.date.issued1990
dc.identifier.urihttp://hdl.handle.net/10920/24660
dc.descriptionvi, 27 p.en_US
dc.description.abstractIt has been shown that significantly lower amounts of Vitamin K-dependent coagulation factors (Factors II, IX, X, Protein C, and total and free Protein S) are found in newborns as compared to adults. This study was designed to determine normal reference values of the amounts of these Vitamin K dependent coagulation proteins in healthy term and preterm infants and to conduct a comparison of these values between the two groups. Plasma samples were obtained from 25 premature and 45 full-term infants and subjected to immunoelectrophoresis and biological activity assays. In comparing the means of the antigen levels of each of the SIX factors in the term group to the corresponding means in the preterm group, no significant difference for Factor X or total Protein S was found. However, antigen levels of Factor II, Factor IX, and Protein C were found to be significantly lower in the preterm group than in the full-term group with P< 0.001 for all three. In addition, free Protein S was found in significantly higher levels in the preterm than in the term group with P< 0.001. Yet, despite these results no direct correlation was found between factor levels and gestational age, r< 0.10 for all Vitamin K-dependent factors studied in the premature infants. The results of this study suggest that partial liver immaturity and a natural selective maturation pattern of the coagulation system may allow for the variation of the amounts of Factors II, IX, X, and Protein C found in premature and full-term infants. The levels of Protein S found may be due to the fact that Protein S is synthesized in the vascular endothelium.en_US
dc.description.sponsorshipPathology Department. School of Medicine. Wayne State University. Detroit, Michigan.
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen_US
dc.relation.ispartofKalamazoo College Health Sciences Senior Individualized Projects Collection
dc.relation.ispartofseriesSenior Individualized Projects. Health Sciences;
dc.rightsU.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder. All rights reserved.
dc.titleVitamin K-Dependent Coagulation Factor Levels in the Cord Blood of Full-Term and Premature Infants: An Establishment of Normal Reference Values and Comparison of Factor Levels Between Term and Preterm Infantsen_US
dc.typeThesisen_US
KCollege.Access.ContactIf you are not a current Kalamazoo College student, faculty, or staff member, email dspace@kzoo.edu to request access to this thesis.


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