Experimental Implantation and Evaluation of Mitral Valves in Sheep
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Authors
Hartker, Frederick W. (Rick)
Issue Date
1990
Type
Thesis
Language
en_US
Keywords
Alternative Title
Abstract
With the development of cardiopulmonary bypass in 1960,
cardiac valve replacement became the most popular method of
treatment for severe cardiac valve disease. Since that time, valve
replacement operations have become increasingly common and the
number of replacement valve types has grown. Thus, it is quite
important that the surgical techniques of implantation be perfected
and that different valve types be tested to determine the most
suitable replacement valve.
During my study, we performed 28 mitral valve implantations
on sheep. By making subtle changes in the conventional implant
methodology we were able to reduce the amount of time our sheep
were on cardiopulmonary bypass. After implantation, hemodynamic
studies were done on implanted mechanical valves. These studies
indicated that the Starr-Edwards valve (ball and cage type) offered
the least flow resistance followed closely by the St. Jude Medical
valve (bileaflet type). Demonstrating somewhat higher flow
resistance was the Medtronic-Hall valve (tilting disk type). The
remaining implanted valves were gluteraldehyde-preserved
homografts. The hemodynamics of these valves were not tested
since the main objective after these implantations was simply to
revive the sheep so that these valves could be studied upon explant
(some 6 months later).
Description
33 p.
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