Analyses of Fibrinogen and Coagulation Factor Levels in Blood from Normal and Congestive Heart Failure Dogs
Henry, Jerald W.
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The relationship between thromboembolic events and congestive heart failure has yet to be elucidated. Therefore we studied the levels of fibrinogen and the coagulation factors in stored pooled dog plasma, fresh normal dog plasma, and congestive heart failure (CHF) dog plasma. The fibrinogen levels were not significantly different, with the CHF fibrinogen levels slightly higher. In comparison to the reported human fibrinogen levels, dog plasma was found to have almost twice the concentration of fibrinogen. Several different coagulation factors in each plasma type were measured to determine any differences or similarities in factor levels. The Prothrombin Time (PT) tests for factors V, VII, and X revealed longer clotting times for the CHF dogs versus the control dogs. The Activated Partial Thromboplastin Time (APTT) tests for factors VIII and XII were less conclusive, but showed a significant rise in clotting time for the CHF dog plasma in the factor XII assay. In both the PT and the APTT tests, the stored plasma had a very prolonged clotting time compared to the other plasma samples. Although the fibrinogen level was slightly higher in CHF dogs, the levels of coagulation factors V, VII, X, and XII were found to be significantly lower.