From Olfactory bulb to higher brain centers: Topography within secondary olfactory pathways in Mice
Loading...
Authors
Kompella, Sindhura
Issue Date
2009
Type
Thesis
Language
en_US
Keywords
Alternative Title
Abstract
In the vertebrate olfactory system, odor information is represented as
topographic map in the olfactory bulb (OB, Schoenfeld et aI., 1996). However it remains
unknown how this odor map is transferred from the olfactory bulb to olfactory cortex
which includes anterior olfactory nucleus (AON) and piriform cortex. During
experimentation with viral tracers and confocal visualization techniques in mice, we
found that most of the projections from olfactory bulb end at layer Ib of piriform cortex
which is a part of olfactory cortex. Furthermore, tracing mitral cell (Me) axons from
olfactory bulb to piriform cortex revealed that individual Mes send axons to multiple
target regions in the forebrain, and the Mes innervating from glomeruli take the
trajectory from anterior olfactory nucleus to piriform cortex mainly end at layer Ib of the
piriform cortex.
Therefore, considering previous studies, we proposed that the topographic
odor map in the olfactory bulb is not maintained intact, but reorganized in the olfactory
cortex. Moreover, our findings of layer specificity and cell specificity using viral tracers
within the piriform cortex rendered the olfactory cortex an attractive model for the
studies of anatomy and function of olfactory bulb.
Description
v, 31 p.
Citation
Publisher
Kalamazoo College
License
U.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.