Effects of anticancer agents on the growth of human colorectal cancer cells xenograft in nude mice
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Authors
White, Rossi N.
Issue Date
2009
Type
Thesis
Language
en_US
Keywords
Alternative Title
Abstract
Cancer accounts for more drug related fatalities in the United States than any
other disease related illness, which is why preclinical research and drug development is a
popular topic in science today. One of the most important anticancer drug development
models is the subcutaneous tumor xenograft model in the nude athymic mouse. The
tumor xenograft model was used in this study with various dose regimes of fluorouracil
and irinotecan in order to develop a better positive control for future preclinical
anticancer drug research. Both drugs were administered alone at different concentrations,
and one combination dose was administered with both irinotecan and fluorouracil.
lrinotecan was found to be most effective at a dose of 150 mg/kg in decreasing tumor size
while also keeping the mice alive and healthy. The combination therapy of 75 mg/kg
irinotecan and 50 mglkg of fluorouracil also showed anti-tumor activity and post
administration recovery, however, this dose was more toxic than 150 mg/kg of irinotecan
alone. In conclusion, irinotecan at a dose of 150 mg/kg was determined to be the best
positive control in this experiment. Future studies should incorporate various routes of
drug administration, tumor growth models, and other available chemotherapeutic drugs in
combination with fluorouracil and irinotecan.
Description
v, 28 p.
Citation
Publisher
Kalamazoo College
License
U.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.