Study of Nicotinic, Muscarinic, and Ionotropic Glutamate Receptors in Kindled Rat Brain and Correlation with Behavior During Kindling in Preparation for Autoradiography
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Authors
Ketchum, Sarah
Issue Date
1996
Type
Thesis
Language
en_US
Keywords
Alternative Title
Abstract
Post-traumatic epilepsy (PTE) is a common medical condition in people who
have suffered severe head injuries. We are using periodic, low-level electrical
stimulation of rat brain to mimic biochemical changes that occur in the brains of
patients with PTE. During this process, known as kindling, no behavioral effects are
observable in the first several days; however, an electrical effect called the
afterdischarge (AD) is seen. The AD is necessary for kindling to develop seizures.
With repeated stimulations, increasing behavioral and electrical seizures are seen. I
examine patterns in behavioral activity during the kindling process in Sprague-Dawley
rats, as well as comparing this information with an older kindling study.
Preliminary assays are done to elucidate an effective method for getting accurate
results in autoradiography. Using these methods, we will look for changes in the
nicotinic, muscarinic, ionotropic glutamate receptor densities in specific regions of
kindled rat brain.
Description
vii, 56 p.
Citation
Publisher
Kalamazoo College
License
U.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.