Show simple item record

dc.contributor.advisorMohammed, Sulma
dc.contributor.authorGeneczko, Charles M.
dc.descriptionv, 31 p.en_US
dc.description.abstractIntraepithelial neoplasia is a significant precancerous lesion that poses a high risk of developing into clinical cancer. The prevalence and association of mammary interaepethial neoplasia (MIN) and spontaneous canine mammary cancer have not been investigated. The purpose of this study is to determine the prevalence of MIN and its association with spontaneous canine mammary carcinoma. Formalin-fixed tissues from 13 normal dogs and 20 dogs with mammary carcinoma were evaluated for the presence of MIN. Estrogen receptor status was examined by immunohistochemistry; the original Estrogen Receptor protocol designed for humans proved ineffective, however, strong staining was eventually achieved. From this pilot study we could conclude that MIN is present in canine mammary carcinoma. These results indicate that canine mammary carcinoma could serve as a model for breast cancer development and progression. Different chemoprevention strategies could be used to targets MIN in canine mammary cancers.en_US
dc.description.sponsorshipDepartment of Veterinary Pathobiology. Purdue University. West Lafayette, Indiana.
dc.publisherKalamazoo Collegeen_US
dc.relation.ispartofKalamazoo College Biology Senior Individualized Projects Collection
dc.relation.ispartofseriesSenior Individualized Projects. Biology;
dc.rightsU.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.
dc.titleOccurrence of Spontaneous Mammary Intraepithelial Neoplasia in the Canine Mammary Glands and Estrogen Receptor Reactivityen_US
KCollege.Access.ContactIf you are not a current Kalamazoo College student, faculty, or staff member, email to request access to this thesis.

Files in this item


This item appears in the following Collection(s)

  • Biology Senior Individualized Projects [1581]
    This collection includes Senior Individualized Projects (SIP's) completed in the Biology Department. Abstracts are generally available to the public, but PDF files are available only to current Kalamazoo College students, faculty, and staff.

Show simple item record