Occurrence of Spontaneous Mammary Intraepithelial Neoplasia in the Canine Mammary Glands and Estrogen Receptor Reactivity
Geneczko, Charles M.
MetadataShow full item record
Intraepithelial neoplasia is a significant precancerous lesion that poses a high risk of developing into clinical cancer. The prevalence and association of mammary interaepethial neoplasia (MIN) and spontaneous canine mammary cancer have not been investigated. The purpose of this study is to determine the prevalence of MIN and its association with spontaneous canine mammary carcinoma. Formalin-fixed tissues from 13 normal dogs and 20 dogs with mammary carcinoma were evaluated for the presence of MIN. Estrogen receptor status was examined by immunohistochemistry; the original Estrogen Receptor protocol designed for humans proved ineffective, however, strong staining was eventually achieved. From this pilot study we could conclude that MIN is present in canine mammary carcinoma. These results indicate that canine mammary carcinoma could serve as a model for breast cancer development and progression. Different chemoprevention strategies could be used to targets MIN in canine mammary cancers.
Showing items related by title, author, creator and subject.
Occurrence of Spontaneous Mammary Intraepithelial Neoplasia in the Canine Mammary Glands and Estrogen Receptor Reactivity Geneczko, Charles M. (Kalamazoo College, 2004)Cancer is one of the leading causes of death in both man and dog. Dogs, however, develop tumors approximately twice as frequently as their human counterparts. Studies have found that 45% of dogs that live to be 10 years ...
Effects of Growth Factors on Proliferation and Differentiation of Human Mammary Stem/Progenitor Cells Foley, Jessica M. (Kalamazoo College, 2003)Stem/progenitor cells (SPC) are the multi-potent progenitors that give rise to all mammary gland lineages. With cancer biology beginning to focus on tumorigenic stem cells as being the origin of clinically relevant ...
Partial Purification and Characterization of a Growth Inhibitor Produced By Normal Rat Mammary Epithelial Cells in Vitro Van De Velde, Rochelle M. (1988)Transforming growth factors (TGFs) have been operationally defined as peptides that reversibly induce nonneoplastic cells to express the transformed phenotype as measured by loss of density-dependent inhibition of growth ...