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dc.contributor.advisorArnoczky, Steven P.
dc.contributor.advisorSotherland, Paul R., 1953-
dc.contributor.authorFrank, Katherine J.
dc.descriptionv, 24 p.en_US
dc.description.abstractThe purpose of this study was to determine the effect of stress deprivation on the diameter and area density of collagen fibrils in rat tail tendons and to correlate the results with changes in stiffness in the tendons. We deprived tendons of stress by immobilizing them in media for 21 days and analyzed them against controls using transmission electron microscopy for fibril diameter and area, mechanical testing for stiffness and northern blot assay for production of interstitial collagenase, which occurs after stress deprivation. Collagen fibril morphology remained statistically unchanged while stiffness decreased and collagenase production increased. These results indicate that collagen fibril size is not solely responsible for decrease in stiffness after stress deprivation and that more investigation into the physiological cause for mechanical failure in tendons must occur.en_US
dc.description.sponsorshipLaboratory for Comparative Orhopaedic Research. Michigan State University. East Lansing, Michigan.
dc.publisherKalamazoo Collegeen_US
dc.relation.ispartofKalamazoo College Biology Senior Individualized Projects Collection
dc.relation.ispartofseriesSenior Individualized Projects. Biology;
dc.rightsU.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.
dc.titleMorphological Effect of Immobilization on Collagen Febrils in Rat Tail Tendonsen_US
KCollege.Access.ContactIf you are not a current Kalamazoo College student, faculty, or staff member, email to request access to this thesis.

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  • Biology Senior Individualized Projects [1520]
    This collection includes Senior Individualized Projects (SIP's) completed in the Biology Department. Abstracts are generally available to the public, but PDF files are available only to current Kalamazoo College students, faculty, and staff.

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