The Importance of Cell Migration inInnate Immunity: Characterization of the BCL-6 -/- BMM Phenotype and of the PBM-Derived Macrophage Phenotype Associated with a Novel Immunodeficiency
Immunity encapsulates two distinct, albeit functionally interdependent, components-innate immunity and acquired immunity. The characteristic specificity of acquired immune components results in a delayed response during which the innate immune response remains the first line of defense against infection. Should infection occur, it is the job of specialized phagocytic cells called "professional phagocytes" -- neutrophils, monocytes, and macrophages -- to detect, track down, and eliminate the invader. Of fundamental importance to macrophages and other professional phagocytes, whose primary function requires long-distance migration, is efficient means of cell migration. Macrophage motility is mechanically linked to cell polarity, and depends upon the continuous, spatiotemporal-coordinated regulation of actin cytoskeleton organization. Because innate immunity is relies heavily on phagocyte migration, those challenges to immunity that reduce phagocyte motility are most successful. Reported here are the results of two separate phenotype characterizations of macrophages harvested from sources with negligible immunity-either BCL-6 -/- - mice or a human patient called FG with a novel immunodeficiency. Each study discovered significant differences between control macrophages and BCL-6 -/- or FG macrophages in comparisons of morphological variables indicative of cell migration. The motility of macrophages from both the BCL-6 -/- condition and the novel immunodeficiency was significantly more impaired than that of control macrophages, clearly demonstrating the importance of cell migration in innate immunity.
Showing items related by title, author, creator and subject.
Effects of Bacterial Metabolite Butyrate and Fiber-Free Diet on Allergic Phenotype in a Murine Model of Peanut Allergy Mailing, Lucy (Kalamazoo, Mich. : Kalamazoo College, 2015)Food allergies have become an epidemic in our modern world. Between 1997 and 2007, the CDC documented an 18% increase in the prevalence of food allergy in children. Recent scientific research has turned to the microbiota, ...
Butryn, Robert Kevin (1990)Tumor cells have been shown to develop drug-resistance in a large number of cancers. The resistant portion of tumor cells is important in the treatment of cancer because it is less sensitive to chemotherapy. The purpose ...
Hazel, Thomas (Kalamazoo College, 1986)Prostatic carcinoma is the second most common form of cancer among human males after lung cancer. The difficulty encountered in attempting to culture adult human prostate epithelial cells has prevented sufficient studies ...