The Importance of Cell Migration inInnate Immunity: Characterization of the BCL-6 -/- BMM Phenotype and of the PBM-Derived Macrophage Phenotype Associated with a Novel Immunodeficiency
Gordon, Amy R.
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Immunity encapsulates two distinct, albeit functionally interdependent, components-innate immunity and acquired immunity. The characteristic specificity of acquired immune components results in a delayed response during which the innate immune response remains the first line of defense against infection. Should infection occur, it is the job of specialized phagocytic cells called "professional phagocytes" -- neutrophils, monocytes, and macrophages -- to detect, track down, and eliminate the invader. Of fundamental importance to macrophages and other professional phagocytes, whose primary function requires long-distance migration, is efficient means of cell migration. Macrophage motility is mechanically linked to cell polarity, and depends upon the continuous, spatiotemporal-coordinated regulation of actin cytoskeleton organization. Because innate immunity is relies heavily on phagocyte migration, those challenges to immunity that reduce phagocyte motility are most successful. Reported here are the results of two separate phenotype characterizations of macrophages harvested from sources with negligible immunity-either BCL-6 -/- - mice or a human patient called FG with a novel immunodeficiency. Each study discovered significant differences between control macrophages and BCL-6 -/- or FG macrophages in comparisons of morphological variables indicative of cell migration. The motility of macrophages from both the BCL-6 -/- condition and the novel immunodeficiency was significantly more impaired than that of control macrophages, clearly demonstrating the importance of cell migration in innate immunity.
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