The Influence of Gestational Age at Delivery on Placental Morphology and Perinatal Outcomes in Pregnancies Complicated by Preeclampsia
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Authors
Puretz, Lauren
Issue Date
2004
Type
Thesis
Language
en_US
Keywords
Alternative Title
Abstract
Preeclampsia is a pregnancy specific syndrome that is associated with significant
perinatal morbidity and mortality. The etiology remains unclear and is likely
multifactorial. The impact of preeclampsia on fetal growth and perinatal brain injury
warrants further research. This was a retroprospective, observational hospital-based
study of maternal characteristics, fetal and maternal thrombophilia risks, placental
morphology and perinatal outcomes in pregnancies complicated by preeclampsia. This
study reviewed the role of placental vascular abnormalities, inherited maternal and fetal
thrombophilic tendencies in the etiology of preeclampsia. Evidence presented uterine
vascular abnormality and serum activities of pro inflammatory cytokines in preeclampsia
were less severe in preeclamptic pregnancies carried to term compared to those that end in preterm delivery. Placental infarction and perinatal brain injury occur more frequently in pregnancies complicated by preeclampsia and inherited thrombophilia in the mother and infant.
Description
v, 34 p.
Citation
Publisher
Kalamazoo College
License
U.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.