The Influence of Gestational Age at Delivery on Placental Morphology and Perinatal Outcomes in Pregnancies Complicated by Preeclampsia
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Preeclampsia is a pregnancy specific syndrome that is associated with significant perinatal morbidity and mortality. The etiology remains unclear and is likely multifactorial. The impact of preeclampsia on fetal growth and perinatal brain injury warrants further research. This was a retroprospective, observational hospital-based study of maternal characteristics, fetal and maternal thrombophilia risks, placental morphology and perinatal outcomes in pregnancies complicated by preeclampsia. This study reviewed the role of placental vascular abnormalities, inherited maternal and fetal thrombophilic tendencies in the etiology of preeclampsia. Evidence presented uterine vascular abnormality and serum activities of pro inflammatory cytokines in preeclampsia were less severe in preeclamptic pregnancies carried to term compared to those that end in preterm delivery. Placental infarction and perinatal brain injury occur more frequently in pregnancies complicated by preeclampsia and inherited thrombophilia in the mother and infant.