Development of a Carrier Which Induces Endochondral Bone Differentiation Activity whith Osteogenic Protein In Vivo
Richmond, Emilie A.
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Subcutaneous implantation of osteogenic Protein (OP) with a collagenous bone matrix induces endochondral bone differentiation in vivo. The OP with biological activity can be purified from any mammalian species, but successful bone induction requires the presence of a species specific collagenous bone matrix. In order for the OP to be useful for human application, a chemically defined, biologically acceptable carrier is necessary. certain commercially available ceramics, biopolymers, and hypoimmunogenic bovine skin and tendon collagens were implanted with OP in vivo to test for their ability to support bone growth. In addition, the modulating role of two growth factors, (designated GFl and GF2 due to proprietary rights) which are normally present in bone, was also studied. The results demonstrate that ceramics, biopolymers and bovine skin collagens are ineffective in inducing bone in vivo. studies on the growth factors suggest that they appeared to have a modulating role on bone differentiation in vivo.