An Examination of Protein Kinase C Using Alzheimer's Disease Models
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Authors
Tinklenberg, James
Issue Date
1989
Type
Thesis
Language
en_US
Keywords
Alternative Title
Abstract
The protein levels and enzyme activity of protein kinase C, a key
phosphorylating enzyme, were examined in two models for the
clinical study of Alzheimer's disease. In the first model, which
involves aspiration of a key set of cholinergic neurons called the
fimbria-fornix, a relationship between aspiration and the protein
levels in the medial septum and hippocampus could not be
established. Specific activity increased in the medial septum after
aspiration, but decreased in hippocampus after aspiration and in
both these brain regions after nerve growth factor treatment. In the
second model, the protein levels and specific enzyme activities of
protein kinase C were examined in the fibroblasts of Alzheimer's
disease patients, where no significant changes in protein level or
enzyme activity were detected in relation to control fibroblasts.
Although the results of the first model may mimic the repair
mechanisms of Alzheimer brain, these initial results have been
interpreted to mean that further study of protein kinase C in these
models does not appear to hold great promise.
Description
v, 43 p.
Citation
Publisher
Kalamazoo College
License
U.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.