An Examination of Protein Kinase C Using Alzheimer's Disease Models
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The protein levels and enzyme activity of protein kinase C, a key phosphorylating enzyme, were examined in two models for the clinical study of Alzheimer's disease. In the first model, which involves aspiration of a key set of cholinergic neurons called the fimbria-fornix, a relationship between aspiration and the protein levels in the medial septum and hippocampus could not be established. Specific activity increased in the medial septum after aspiration, but decreased in hippocampus after aspiration and in both these brain regions after nerve growth factor treatment. In the second model, the protein levels and specific enzyme activities of protein kinase C were examined in the fibroblasts of Alzheimer's disease patients, where no significant changes in protein level or enzyme activity were detected in relation to control fibroblasts. Although the results of the first model may mimic the repair mechanisms of Alzheimer brain, these initial results have been interpreted to mean that further study of protein kinase C in these models does not appear to hold great promise.