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dc.contributor.advisorRuwart, Mary J.
dc.contributor.authorHoover, Jennifer Leigh
dc.descriptionXIII, 128 p.en_US
dc.description.abstractPeptide drugs represent an important therapeutic pharmaceutical class for the treatment of many chronic illnesses. Unfortunately, oral administration, the most favored delivery route, often results in extremely low absorption due to degradation in the gastrointestinal (GI) tract and frequent "first pass" liver clearance. The low bioavailability and biological activity, following oral administration, makes this route less than optimal for the delivery of peptide drugs. Therefore the intrapulmonary route was investigated. Synthetic model peptides, which varied systematically in molecular mass, hydrogen bond number, and lipophilicity were administered into the lungs to determine the factors which affect intrapulmonary absorption. The results suggest that the major determinant of gut absorption, hydrogen bond number, plays no significant role in absorption from the lung. Additional intrapulmonary administration studies were performed with two potential drug candidates, U77436, a renIn inhibitor and U75875, an HIV protease inhibitor. Each peptide exhibited "sustained release" over ten hours. All peptides exhibited greater than 50% absorption, suggesting that the intrapulmonary route is a promising alternative to oral peptide delivery.en_US
dc.description.sponsorshipDrug Delivery Systems Research and Development. Upjohn Company. Kalamazoo, Michigan.
dc.publisherKalamazoo Collegeen_US
dc.relation.ispartofKalamazoo College Biology Senior Individualized Projects Collection
dc.relation.ispartofseriesSenior Individualized Projects. Biology;
dc.rightsU.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.
dc.titleIntrapulmonary Administration of Peptide Drugs In a Unique Rat Model: Increased Drug Absorption and Avoidance of "First Pass" Liver Clearanceen_US
KCollege.Access.ContactIf you are not a current Kalamazoo College student, faculty, or staff member, email to request access to this thesis.

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  • Biology Senior Individualized Projects [1548]
    This collection includes Senior Individualized Projects (SIP's) completed in the Biology Department. Abstracts are generally available to the public, but PDF files are available only to current Kalamazoo College students, faculty, and staff.

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