The Effects of Phencyclidine and Haloperidol on Glucose Metabolism in Rat Brain
Ray, Catherine A.
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Schizophrenia is the classic disease of madness. Because it is a neurological disfunction, research has been difficult both in terms of finding an underlying cause and in discovering better treatments. For this reason, a drug that induces a state mimetic of schizophrenia is needed for experimental purposes. Phencyclidine (PCP) can induce a state that is often clinically indistinguishable from schizophrenia. Sokoloff's (1977) 14c-2-deoxyglucose technique is used to determine local cerebral glucose utilization (LCGU) in the brain. The method is based upon the principle that glucose utilization in the brain cells is altered by malfunctions and abnormalities. This experiment used the Sokoloff method to determine the effects of PCP on glucose utilization. Haloperidol is a neuroleptic drug that is often used to treat schizophrenia as well as PCP intoxication. The Sokoloff method was also used to study the effect haloperidol had upon the phencyclidine induced glucose utilization changes in the brain. The PCP results correlated well with other PCP studies. Haloperidol appears generally to depress several brain regions. However, in the PCP stimulated Papez circuit and in PCP-receptor regions, haloperidol did not have a significant effect upon LCGU.