Blood Pressure Response to an Endogenous Alpha-Two Antagonist Injected into the Fourth Ventricle of the Rat
Stone, Steven J.
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In this project, Adrenergic Binding Inhibitor, an endogenous alpha-two antagonist isolated from the pig duodenum, was injected into the fourth ventricle of metofane-anesthetized rats to determine its effect on blood pressure. Injections of Adrenergic Binding Inhibitor showed a dose-dependent decrease in mean arterial pressure. The duration of the hypotensive responses was found to be dose-dependent as well. This study strongly suggests that Adrenergic Binding Inhibitor is biologically potent, and that it exerts its effect through the activation of the alpha-two receptor. Before the injections were performed, a reliable system for making intracranial chemical injections was first developed using clonidine to elicit a "typical type" of depressor response.