Cortico-Cortical Projection to the Inferior Prefrontal Cortex Via the Uncinate Fascicle in the Rhesus Monkey
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Authors
Pelak, Victoria S.
Issue Date
1987
Type
Thesis
Language
en_US
Keywords
Alternative Title
Abstract
The cortico-cortical projection from the anterior portion of the
temporal lobe to the inferior prefrontal cortex by way of the uncinate
fascicle in the rhesus monkey (Macaca mulatta) was investigated. In
order to trace the pathway of the uncinate fascicle, one monkey was
injected with tritiated amino acids, which are retrogradely
transported, in the anterior inferior temporal cortex. Another monkey
received bilateral injections of the inferior prefrontal cortex with
two fluorescent dyes, which are anterogradely transported, in order to
determine all the regions projecting to this cortex. In two other
monkeys, unilateral lesions of the uncinate fascicle were made, and a
fluorescent dye was injected in the inferior prefrontal cortex of the
same hemisphere, in order to determine the precise areas that send
projections through this fiber bundle. The uncinate fascicle was
observed to project anteriorly from the inferior temporal cortex, and
then to course dorsally toward the inferior prefrontal cortex, where it
terminates in the inferior limb of the arcuate sulcus and on the
inferior prefrontal convexity ventral to the principal sulcus. Regions
in the temporal cortex that were found to project to the prefrontal
cortex via the uncinate fascicle include the rostral portion of areas
TA and TE, area TG, and possibly anterior portions of area STP. The
premotor cortex and areas PF and PG were also found to project to
prefrontal cortex, but these regions do not project via the uncinate
fascicle.
Description
v, 37 p.
Citation
Publisher
Kalamazoo College
License
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