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dc.contributor.advisorMarks, Thomas A.
dc.contributor.advisorPoppe, Susan M.
dc.contributor.authorHasler, James M.
dc.descriptioniii, 24 p.en_US
dc.description.abstractLosulazine was administered orally by gastric intubation to Sprague-Dawley rats at treatment levels of 0, 4 and 8 mg/kg/day in a neonatal development and reproductive performance study. Twenty-four females were treated at each level in three sections; Section A was treated from postpartum day 0 through postpartum day 4; Section B was treated postpartum day 0 through postpartum day 10; and, Section C was treated postpartum day 0 through postpartum day 21. There were significant decreases in maternal weight gain during treatment in a dose-related manner. Live pup weight means also decreased in a dose-related manner in all sections, persisting throughout maturation in F1 males and to about week nine in F1 females. Significant delays were recorded in the developmental milestone of eye opening. There was also a significant reduction in the copulation rate of F1 females in a dose-related trend.en_US
dc.description.sponsorshipUpjohn Company, Kalamazoo, MI
dc.publisherKalamazoo Collegeen_US
dc.relation.ispartofKalamazoo College Biology Senior Individualized Projects Collection
dc.relation.ispartofseriesSenior Individualized Projects. Biology;
dc.rightsU.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.
dc.titleThe Effects of Losulazine on the Neonatal Development of the Sprague Dawley Raten_US
KCollege.Access.ContactIf you are not a current Kalamazoo College student, faculty, or staff member, email to request access to this thesis.

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  • Biology Senior Individualized Projects [1489]
    This collection includes Senior Individualized Projects (SIP's) completed in the Biology Department. Abstracts are generally available to the public, but PDF files are available only to current Kalamazoo College students, faculty, and staff.

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