The Effects of Losulazine on the Neonatal Development of the Sprague Dawley Rat
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Authors
Hasler, James M.
Issue Date
1987
Type
Thesis
Language
en_US
Keywords
Alternative Title
Abstract
Losulazine was administered orally by gastric
intubation to Sprague-Dawley rats at treatment levels
of 0, 4 and 8 mg/kg/day in a neonatal development and
reproductive performance study. Twenty-four females
were treated at each level in three sections; Section A
was treated from postpartum day 0 through postpartum
day 4; Section B was treated postpartum day 0 through
postpartum day 10; and, Section C was treated
postpartum day 0 through postpartum day 21. There were
significant decreases in maternal weight gain during
treatment in a dose-related manner. Live pup weight
means also decreased in a dose-related manner in all
sections, persisting throughout maturation in F1 males
and to about week nine in F1 females. Significant
delays were recorded in the developmental milestone of
eye opening. There was also a significant reduction in
the copulation rate of F1 females in a dose-related
trend.
Description
iii, 24 p.
Citation
Publisher
Kalamazoo College
License
U.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.