The Effects of Losulazine on the Neonatal Development of the Sprague Dawley Rat
Hasler, James M.
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Losulazine was administered orally by gastric intubation to Sprague-Dawley rats at treatment levels of 0, 4 and 8 mg/kg/day in a neonatal development and reproductive performance study. Twenty-four females were treated at each level in three sections; Section A was treated from postpartum day 0 through postpartum day 4; Section B was treated postpartum day 0 through postpartum day 10; and, Section C was treated postpartum day 0 through postpartum day 21. There were significant decreases in maternal weight gain during treatment in a dose-related manner. Live pup weight means also decreased in a dose-related manner in all sections, persisting throughout maturation in F1 males and to about week nine in F1 females. Significant delays were recorded in the developmental milestone of eye opening. There was also a significant reduction in the copulation rate of F1 females in a dose-related trend.