Potentiation of Antitumor Activity with Calf Thymus DNA against P388 Lymphocytic Leukemia
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Authors
Bossenberry, Stephen
Issue Date
1983
Type
Thesis
Language
en_US
Keywords
Alternative Title
Abstract
Four antitumor antibiotics were tested with calf thymus
DNA type I, both in combination and when complexed to this
macromolecule in BDF/l mice tumored with P388 lymphocytic
leukemia. The antitumor activity of actinomycin D or
adriamycin was potentiated when DNA was given one-half hour
after administration of the drug, as well as when the
antibiotic and DNA were given as a complex. No potentiation of
antitumor activity of menogarol (7-0MEN) was seen in
combination or when complexed with DNA. The activity of
CC-l065 was potentiated slightly and a dramatic reduction in
toxicity attributed to the drug itself was observed when this
antibiotic was given in combination with DNA at the optimal
dose of 0.04 mg/kg. Evidence of toxicity was absent when
CC-l065 and DNA were complexed with one another.
Description
iv, 33 p.
Citation
Publisher
Kalamazoo College
License
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