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dc.contributor.advisorFischbach, Gerald D.
dc.contributor.authorForsch, Randall T.
dc.descriptioniii, 45 p.en_US
dc.description.abstractThe early events in the in vitro formation of the neuromuscular junction have yet to be entirely revealed. Using an in vitro chick embryonic ciliary ganglion neuron/skeletal muscle system, experiments were undertaken to determine the time-course for the appearance of AChR clustering, the location of these clusters, and the role of extra-junctional and junctional AChR in this early clustering. Neuron and muscle tissue culture, AChR marking with fluorescently-labelled α-bungarotoxin and anti-AChR monoclonal anti-bodies, and time-lapse cinemicroscopy were used extensively. It was determined that AChR aggregation probably occurs within 3 to 4 hours after contact with the neuron's soma and/or growth cone. The AChR involved appear to be extra-junctional.en_US
dc.publisherKalamazoo Collegeen_US
dc.relation.ispartofKalamazoo College Biology Senior Individualized Projects Collection
dc.relation.ispartofseriesSenior Individualized Projects. Biology;
dc.rightsU.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.
dc.titleObservation of Acetylcholine Receptor Aggregation at In Vitro Chick Nerve/Muscle Contractsen_US
KCollege.Access.ContactIf you are not a current Kalamazoo College student, faculty, or staff member, email to request access to this thesis.

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  • Biology Senior Individualized Projects [1489]
    This collection includes Senior Individualized Projects (SIP's) completed in the Biology Department. Abstracts are generally available to the public, but PDF files are available only to current Kalamazoo College students, faculty, and staff.

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