Preliminary Studies of the Development of the Cholinergic System in the Visual Cortex
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Authors
Seifert, George
Issue Date
1983
Type
Thesis
Language
en_US
Keywords
Alternative Title
Abstract
While much is known of the noradrenergic and serotenergic
systems within the central nervous system (CNS), the
cholinergic and its development remain relatively ambiguous.
A project was begun in which cholinergic cells in the visual
cortex were studied using electrophysiological techniques.
A metal electrode was inserted in one barrel of a five-barrel
glass pipette in order to record activity of single neurons
in the cortex while the other barrels were used to apply
cholinergic drugs using microiontophoretic techniques. The
electrode was inserted in the cortex of paralyzed, anesthetized
adult cats and neuronal activity observed. Cells were
classified according to the Hubel and Weisel system for simple
and complex cells and the system of Kato, Bishop and Orban
to determine hypercomplexity. The effect of the drug on the
response of a single neuron to visual stimulation was studied
and the cholinergic system characterized. It was found that
the results lended support to a model of parallel processing
of information in the brain. Ultimately, comparisons of
cells in adult cats and of cells in kittens will reveal
important aspects of the development of the cholinergic
system in the mammalian CNS.
Description
iv, 34 p.
Citation
Publisher
Kalamazoo College
License
U.S. copyright laws protect this material. Commercial use or distribution of this material is not permitted without prior written permission of the copyright holder.