The Effect of a Lipoxygenase Inhibitor on the Adhesion and Migration of Feline Leukocytes
Romano, Peter J. II
MetadataShow full item record
Deep vein thrombosis (DVT) is a serious post-operative complication of unclear etiology. Leukocytes are believed to play a role in the initiation of DVT by producing leukotrienes. Nordihydroguaiaretic acid (NDGA) is an inhibitor of the enzyme responsible for the production of leukatrienes, thus it may have beneficial effects in preventing DVT. The effect of NDGA on the deposition of leukocytes on feline jugular veins was investigated. Seven cats were used in the study and divided into experimental and control groups. Leukocytes were labeled with Indium-lll, and deposition was quantitated using radioactive and white cell counts. NDGA was shown to be effective in inhibiting leukocyte deposition on the vessel wall. Scanning electron microscopy (SEM) confirmed these results, and also indicated that NDGA reduces endothelial damage resulting from leukocytes. These findings may provide insight toward developing an effective, preventive treatment ·for venous thrombosis.